Identification of Allelic Imbalance with a Statistical Model for Subtle Genomic Mosaicism
نویسندگان
چکیده
منابع مشابه
Identification of Allelic Imbalance with a Statistical Model for Subtle Genomic Mosaicism
Genetic heterogeneity in a mixed sample of tumor and normal DNA can confound characterization of the tumor genome. Numerous computational methods have been proposed to detect aberrations in DNA samples from tumor and normal tissue mixtures. Most of these require tumor purities to be at least 10-15%. Here, we present a statistical model to capture information, contained in the individual's germl...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2014
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003765